European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

Abstract Background Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. Large prospective observational studies have recently increased understanding of effectiveness colonoscopic surveillance and heterogeneity risk between genotypes. The need gene- gender-specific guidelines has been acknowledged. Methods European Hereditary Tumour Group (EHTG) Society Coloproctology (ESCP) developed a multidisciplinary working group consisting surgeons, clinical molecular geneticists, pathologists, epidemiologists, gastroenterologists, patient representation to conduct graded evidence review. previous Mallorca guideline format was used revise guidance. Consensus guidance statements acquired by three Delphi voting rounds. Results Recommendations identification syndrome, surgical endoscopic management syndrome-associated colorectal cancer, preventive measures were produced. emphasis on gastroenterological aspects spectrum. Manchester consensus gynaecological endorsed. Executive layperson summaries provided. Conclusion recommendations from EHTG ESCP patients with surveillance, lifestyle chemoprevention in that reached (at least 80 per cent) are presented.